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A Complete Guide To Laxogenin : Benefits & Side Effects Of 5a-Hydroxy


Laxogenin is often called a prohormone, but is it really a prohormone, or is it a steroid?

Either way, there are plenty of claimed benefits, but is everything as it seems? Is this substance really as effective as claimed? Is it safe to use?

In our guide, we are going to look at this substance in more detail to discover the truth behind the claims. Please continue reading to learn whether you should use it or not.[toc]

What Is Laxogenin?

Laxogenin is an anabolic substance derived from plants, in particular, the plant Smilax Sieboldii, its scientific name is 5-Alpha Hydroxy Laxogenin.

It is a naturally occurring steroidal sapogenin that works as a starting point for semisynthesis of your own steroid hormones.

In nature it is part of a group of plant-based steroids called brassinosteroids. Amazingly, mustard is also a brassinosteroid.

In simple terms, Laxogenin works by helping to build bigger molecules from smaller molecules.

When you workout your muscle fibres are broken down, and with the help of this substance the muscle fibres are repaired and are grown bigger and better prepared for heavier workouts.

History Of Laxogenin

This substance was originally discovered back in the 1940s while undergoing steroid research. It was found in Mexican Yams, which were found to have positive anabolic and androgenic properties.

Originally released to the general public in the early 1990s, it is now found in many online supplement stores, with Smilax used as the main ingredient.

What Is Laxogenin Used For?

Nowadays it is sold online as a muscle-building supplement used by athletes and bodybuilders.

Some companies claim that its use could lead to a 200% increase in protein production in your muscle (muscle protein synthesis).

How Does Laxogenin Work?

Plant steroids work in a different way to human steroid hormones like testosterone. For instance, they only attach to the surface of the cell.

This sets off a signal inside the cell to build muscle [1][2]. Specifically, a protein called AKT1 or protein kinase B is activated. This helps enhance the muscle-building process and helps prevent the breakdown of muscle proteins [3][4][5].

It has also been found that derivatives of this substance can block the enzyme that breaks down cAMP (phosphodiesterase). This subsequently leads to an increase in cAMP, which helps promote the breakdown of fat, while also helping to activate your fight or flight response [6][7].

Laxogenin Benefits

Laxogenin benefits include:

  • Increased Protein Synthesis
  • Stimulated Lean Muscle Growth
  • Enhanced Muscle Recovery
  • Increased Strength

#1: Increase Muscle Mass & Strength

If you train regularly with intensity and get appropriate nutrition then the increased protein synthesis will lead to an increase in muscle mass and strength [8].

#2: Lower Cortisol Levels

Cortisol is a stress hormone that increases the chance of holding onto or gaining body fat. It also reduces your ability to build muscle and get stronger.

It has been shown the supplementing with Laxogenin can reduce cortisol production, therefore increasing your ability to burn fat and build muscle.

#3: Reduced Muscle Soreness & Better Recovery

When you exercise intensely your muscle fibres are torn, this can lead to painful DOMS (delayed-onset muscle soreness) while your body recovers.

It has been shown that this substance can neutralise oxidative stress, which could aid the recovery from exercise [9].

#4: Fight Cancer

Studies have shown that this substance can help fight cancer. With research showing that it could help reduce the formation of lung cancer in mice, while also killing leukaemia and colon cancer cells [10][11][12].

#5: Lower Blood Sugar Levels

Research on obese mice found that brassinosteroids could help reduce blood sugar levels, while also helping to reduce sugar production in the liver and insulin resistance [13].

Laxogenin Side Effects

Compared to many sports supplements and steroids, Laxogenin is pretty safe to use. Animal studies have shown it to be safe. However, no human studies have been undertaken as yet.

It is worth noting that users of supplements that contain Smilax Sieboldii have noted the following side effects [14]:

  • Diarrhoea
  • Excessive urination
  • Headaches
  • Shock

The users who experienced these side effects used high doses (200mg daily).

Laxogenin Dosage

If you are starting out with Laxogenin it is recommended to begin with a smaller dose of 75 mg daily.

Once your body gets used to its effects you could try increasing the dosage up to 100 mg daily.

In both cases, you should cycle for 8 weeks, with 4 weeks off.

The reason for the break is to allow your body time to recuperate, and for your body to feel the initial changes when the cycle restarts.

As the cycle goes on your body will become more tolerant, so it is always advisable to have a break.

Do You Need PCT With Laxogenin?

As this substance does not alter your natural hormonal balance then you won’t need to use any PCT during your cycle.

Laxogenin FAQs

Here are some commonly asked questions:

Does Laxogenin Cause Hair Loss?

It has not been shown to cause hair loss.

Many muscle building supplements will cause an increase in DHT, which may lead to thinning hair, especially in those predisposed to male pattern baldness.

However, Laxogenin does not cause an increase in the production of DHT.

Is Laxogenin Liver Toxic?

No, it is not liver toxic.

What Is The Half-Life Of Laxogenin?

The half-life of Laxogenin is only 6-8 hours. This is considered short, which is why it is recommended to spread the dosage throughout the day.

Is Laxogenin A Prohormone?

This substance is often labelled as a prohormone, however, it is not. It is instead a plant steroid.

Prohormones are a building block for hormone production, with the most common ones (androgenic prohormones) found to convert into testosterone.

Is Laxogenin A Steroid?

It is a natural plant steroid. This substance is not a synthetic steroid.

Is Laxogenin A Banned Substance?

This substance is legal to both buy and sell. It is not listed as prohibited on either the USADA or WADA list so should be safe to use even if you are an athlete or are in the armed services.

I would recommend checking this out yourself as laws can change and may not be applicable in your particular region.

How Much Does Laxogenin Cost?

Typically, Laxogenin will cost between $40 and $60 for a bottle of 60-180 capsules. Dosages will vary from brand to brand so it is essential you perform thorough research on each brand before purchase.

Can Women Use Laxogenin?

This substance can be used by both males and females.

Is Laxogenin Worth It?

Looking at reviews online, it seems as though Laxogenin is an effective muscle builder with very few side effects.

It is completely legal to buy and is natural too. If you are looking to boost your muscle-building efforts then you may want to try it yourself.

How To Buy Laxogenin?

There are plenty of places online where you can buy Laxogenin, including Amazon.

Before handing over your credit card information you should perform some research and compare some of the leading brands.

Many companies won’t perform any third-party testing on their products to ensure that they are safe to use. Others won’t have any quality control at all.

It is best that you choose a company that you have evaluated thoroughly, and that has a long history of producing effective and safe products.

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